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KMID : 0616120110420010076
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 1 p.76 ~ p.81
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Dermal and Ocular Irritation Studies of Honeybee (Apis mellifera L.) venom
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Han Sang-Mi
Lee Kwang-Gill
Yeo Joo-Hong
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Abstract
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The study of irritation and toxicity of honeybee(Apis mellifera. L) venom collected by a bee venom collector applied topically to the skin and mucous membrane were carried out to prove the safety of honeybee venom in clinical use. Animal for the research was the rabbit and the solution for the test was made from honeybee venom. Six animals were used fot the skin test and nine animals were used for the eye mucous membrane test. In results, both tests proved that honeybee venom makes no irritable reaction on skin and eye mucous membrane of rabbit. We consider that this result is helpful for saying about the safety of honeybee venom in clinical use.
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KEYWORD
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Honeybee venom, Skin irritaion, Eye irritaion, Rabbit
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